Associations between P53, Transforming Growth Factor Beta-1, and Interleukin-10 Serum Levels with Advanced Liver Disease and Hepatitis B Virus Infection

Background. Hepatitis B infection can lead to advanced liver disease (ALD) which causes serious health problems. Several factors that are thought play a role in P53, Transforming Growth Factor-β1 (TGF-β1), and Interleukin-10 (IL-10). Therefore, this study aimed determine the association between TGF-β1, IL-10 serum levels with ALD.Methods. We collected 68 sera from patients HBV infection. were measured by ELISA. also detected SNPs P53 TGF-b1 genes determines their associations.Results Conclusions: In study, we obtained 41.18% CH 58.82% ALD patients. Male outnumbered female all groups. There was significant relationship (p = 0.03 0.01, respectively), but not levels. However, there no SNP gene nor 0.73 0.23, respectively).Both leveles act as biomarkers of prognosis target therapy for